therosclerotic plaque and hydroxyapatite nanostructures studied by high-frequency EPR
Abstract
A series of nanosized (20 nm and larger) samples of hydroxyapatite powders synthesized by wet preparation method and doped with Mn2+ and Pb2+ ions were studied by 94 GHz pulsed electron paramagnetic resonance (EPR). The results are compared with those obtained in the samples of aorta walls from male patients with atherosclerosis as well as in bulk hydroxyapatite materials. It is shown that in contrast to bulk materials Pb ions at least partially replace the Ca(1) site in the hydroxyapatite structure. The spectral characteristics of the Mn2+ ions revealed in atherosclerotic plaque and synthetic hydroxyapatite are found to be practically identical. The hypothesis about the important role of (nano)hydroxyapatite in formation and rupture of atherosclerotic plaques is supported.
Supporting agencies: The work was supported by Russian Ministry of Science and Education (state contract No. 16.552.11.7083).
About the Authors
M. R. Gafurov
Kazan Federal University
Russian Federation
Russian Federation
Institute of Physics, Kazan 420008
B. V. Yavkin
Kazan Federal University
Russian Federation
Russian Federation
Institute of Physics, Kazan 420008
T. B. Biktagirov
Kazan Federal University
Russian Federation
Russian Federation
Institute of Physics, Kazan 420008
G. V. Mamin
Kazan Federal University
Russian Federation
Russian Federation
Institute of Physics, Kazan 420008
S. B. Orlinskii
Kazan Federal University
Russian Federation
Russian Federation
Institute of Physics, Kazan 420008
V. V. Izotov
Kazan Federal University
Russian Federation
Russian Federation
Institute of Physics, Kazan 420008
M. Kh. Salakhov
Kazan Federal University
Russian Federation
Russian Federation
Institute of Physics, Kazan 420008
E. S. Klimashina
M.V. Lomonosov Moscow State University, Department of Chemistry
Russian Federation
Russian Federation
Moscow 119992
V. I. Putlayev
M.V. Lomonosov Moscow State University, Department of Chemistry
Russian Federation
Russian Federation
Moscow 119992
V. A. Abdul'yanov
Interregional Clinic and Diagnostic Center
Russian Federation
Russian Federation
Kazan 420101
I. M. Ignatjev
Interregional Clinic and Diagnostic Center
Russian Federation
Russian Federation
Kazan 420101
R. N. Khairullin
Interregional Clinic and Diagnostic Center
Russian Federation
Russian Federation
Kazan 420101
A. V. Zamochkin
Interregional Clinic and Diagnostic Center
Russian Federation
Russian Federation
Kazan 420101
Yu. A. Chelyshev
Kazan Federal University, Institute of Physics; Kazan State Medical University
Russian Federation
Russian Federation
Kazan 420008; 420012 Kazan
References
1. Petrukhin I.S., Lunina E.Y . Public Health Reviews 33, 436 (2012)
2. Weissberg P.L. Heart 83, 247 (2000)
3. Global Atlas on cardiovascular disease prevention and control, World Health Organization, Geneva, 155 p. (2011)
4. Vengrenyuk Y., Carlier S., Xanthos S., Cardoso L., Ganatos P., Virmani R., Einav Sh., Gilchrist L., Weinbaum S. PNAS 103, 14678 (2006)
5. Abdul’yanov V.A., Galiullina L.F., Galyavich A.S., Izotov V.G., Mamin G.V., Orlinskii S.B., Rodionov A.A., Salakhov M.Kh., Silkin N.I., Sitdikova L.M., Khairullin R.N., Chelyshev Yu.A. JETP Lett. 88, 69 (2008)
6. LeGeros R.Z, LeGeros J.P. Ch.16: Hydroxyapatite (pp. 367-394) in “Bioceramics and their clinical applications” by T. Kokubo (Ed.). Woodhead Pub. and Maney Pub., Cambridge, 760 p. (2008)
7. Dorozhkin S.V., Epple M. Angew Chem Int Ed. 41, 3130 (2002)
8. Dorozhkin S.V. Am. J. Biomed. Eng. 2, 48 (2012)
9. Chu S.H., Feng D.F., Ma Y.B., Li Z.Q. Int J Nanomedicine 7, 3659 (2012)
10. Jarcho M., Bolen C.H., Thomas M.B., Bobick J., Kay J.F., Doremus R.H. J. Mater. Sci. 11, 2027 (1976)
11. Kehoe Sh. Optimisation of Hydroxyapatite (HAp) for Orthopaedic Application via the Chemical Precipitation Technique Ph.D. Thesis, Dublin City University, 393 p (2008)
12. Keijser T.De, Langford J.I., Mittemeijer E.J., Vogels A.B.P. J. Appl. Cryst. 15, 3087 (1982)
13. Murphy D.M., Farley R.D. Chem. Soc. Rev. 35, 249 (2006)
14. Silkin N.I., Chelyshev Yu.A., Mamin G.V., Orlinskii S. B., Salakhov M. Kh. Patent RU 2468368
15. Elliott J.C. Studies in Inorganic Chemistry 18, 1 (1994)
16. Nounah A., Maroufi N., Ichou Y., Ait Y, Lacout J.L., Savariault J.M. J. Phys. IV 123, 251 (2005)
17. Yavkin B.V., Mamin G.V., Orlinskii S.B., Gafurov M.R., Salakhov M.Kh., Biktagirov T.B., Klimashina E.S., Putlayev V.I., Tretyakov Yu.D., Silkin N.I. Phys. Chem. Chem. Phys. 14, 2246 (2012)
18. Pounds J.G., Long G.J., Rosen J.F. Environ Health Perspect. 91, 17 (1991)
Review
For citations:
Gafurov M.R., Yavkin B.V., Biktagirov T.B., Mamin G.V., Orlinskii S.B., Izotov V.V., Salakhov M.Kh., Klimashina E.S., Putlayev V.I., Abdul'yanov V.A., Ignatjev I.M., Khairullin R.N., Zamochkin A.V., Chelyshev Yu.A. therosclerotic plaque and hydroxyapatite nanostructures studied by high-frequency EPR. Magnetic Resonance in Solids. 2013;15(1):13102 (7 pp.).
Views:
32
Email this article 