NMR study of cholesterol complexes with glycyrrhizic acid
Abstract
Nuclear magnetic resonance (NMR) relaxation technique was applied to study the interaction of cholesterol with natural complexant - glycyrrhizic acid. Stoichiometry, stability constants and thermodynamic parameters of the complex have been measured. We propose that the complexation with glycyrrhizic acid could be an effective approach to regulate the cholesterol level inside and outside of cage membranes.
Supporting agencies: This work was supported by the Priority Program for Basic Research RAS. Project No 4: “Study of supramolecular complexes of plant metabolites and their derivatives with hypocholesterolemic agents by physicochemical methods”, 2009-2011.
About the Authors
O. Yu. Gluschenko
Institute of Chemical Kinetics and Combustion
Russian Federation
Russian Federation
Institutskaya str., 3, Novosibirsk 630090
N. E. Polyakov
Institute of Chemical Kinetics and Combustion
Russian Federation
Russian Federation
Institutskaya str., 3, Novosibirsk 630090
T. V. Leshina
Institute of Chemical Kinetics and Combustion
Russian Federation
Russian Federation
Institutskaya str., 3, Novosibirsk 630090
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Review
For citations:
Gluschenko O.Yu., Polyakov N.E., Leshina T.V. NMR study of cholesterol complexes with glycyrrhizic acid. Magnetic Resonance in Solids. 2011;13(2):5-9.
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