Preview

Magnetic Resonance in Solids

Advanced search

Obtaining spatial structure of cyclosporine (CsA) in chloroform using 2D NMR

Abstract

In this work the cyclic peptide cyclosporine was investigated. Signal assignment was made according to 2D NMR spectra. Using NOESY spectra and computer simulation the spatial structure was also obtained.

About the Authors

A. Y. Manin
Kazan Federal University
Russian Federation

Kremlevskaya, 18, Kazan 420008



S. V. Efimov
Kazan Federal University
Russian Federation

Kremlevskaya, 18, Kazan 420008



V. V. Klochkov
Kazan Federal University
Russian Federation

Kremlevskaya, 18, Kazan 420008



References

1. Hsu V.L., Heald S.L., Harding M.W., Handschumacher R.E., Armitage I.M. Biochem. Pharm. 40, 131 (1990)

2. Weber C., Wider G., Freyberg B., Traber R., Braun W., Widmer H., Wuthrich K. Biochemistry 30, 6563 (1991)

3. Fesik S.W., Gampe R.T., Eaton H.L., Gemmecker G., Olejniczak E.T., Neri P., Holzman T.F., Egan D.A., Edalji R., Simmer R., Helfrich R., Hochlowski J., Jackson M. Biochemistry 30, 6574 (1991)

4. Yingqing R., Luwei Z., Qing X., Yalkowsky S.H. AAPS PharmSciTech 2, 23 (2001)

5. Delaglio F., Grzesiek S., Vuister G., Zhu G., Pfeifer J., Bax A. J. Biomol. NMR 6, 277 (1995)


Review

For citations:


Manin A.Y., Efimov S.V., Klochkov V.V. Obtaining spatial structure of cyclosporine (CsA) in chloroform using 2D NMR. Magnetic Resonance in Solids. 2011;13(2):21-26.

Views: 29


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2072-5981 (Online)