Inhibition of Water Transport Across Cell Membranes by Dimephosphon
Abstract
The inhibitory effect of widely used drug dimephosphon on water transport in human red cells at 37?C was studied in comparison to intact human erythrocytes. Intracellular water residence time characterizing water permeability of cell membrane was obtained with doping NMR technique. Inhibitory effect of dimephosphon is concentration-dependent.
Supporting agencies: The work was supported by RFBR projects № 04-03-32861, № 06-04-48160 and RNP 2.1.1.3222.
About the Authors
M. V. Sundukova
Kazan State University
Russian Federation
Russian Federation
Kremlevskaya, 18, Kazan 420008
A. R. Mutina
Kazan State University
Russian Federation
Russian Federation
Kremlevskaya, 18, Kazan 420008
A. I. Skorinkin
Kazan State University
Russian Federation
Russian Federation
Kremlevskaya, 18, Kazan 420008
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Review
For citations:
Sundukova M.V., Mutina A.R., Skorinkin A.I. Inhibition of Water Transport Across Cell Membranes by Dimephosphon. Magnetic Resonance in Solids. 2006;8(1):6-9.
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